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The prolongation of the lifespan by repeated oral administration of C60 fullerene
Here is the original study that inspired our interest for Olive Oil carbon 60:
Tarek Baati, Fanchon Bourasset, Najla Gharbi, Leila Njim, Manef Abderrabba, Abdelhamid Kerkeni, Henri Szwarc, Fathi Moussa, The prolongation of the lifespan of rats by repeated oral administration of C60 fullerene, Biomatériaux, Volume 33, Numéro 19, Juin 2012, pages 4936-4946, ISSN 0142-9612, 10.1016 / j.biomaterials.2012.03.036.
Summary:
"Countless studies showed that C60 fullerene and derivatives could have many potential biomedical applications. However, while several independent research groups showed that C60 has no acute or subacute toxicity in various experimental models, more than 25 years after its discovery the in vivo fate and the chronic effects of this fullerene remain unknown.
If the potential of C60 and derivatives in the biomedical field have to be fulfilled these issues must be addressed. Here we show that oral administration of C60 dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their lifespan. The effects of C60-olive oil solutions in an experimental model of CCl4 intoxication in rat strongly suggest that the effect on lifespan is mainly due to the attenuation of age-associated increases in oxidative stress.
Pharmacokinetic studies show that dissolved C60 is absorbed by the gastro-intestinal tract and eliminated in a few tens of hours. These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of C60 including cancer therapy, neurodegenerative disorders, and ageing. Keywords: Fullerene; Toxicity; Pharmacokinetic; Aging; Oxydative Stress"
Conclusion:
The effect of pristine C60 on lifespan emphasizes the absence of chronic toxicity. These results obtained with a small sample of animals with an exploratory protocol ask for a more extensive studies to optimize the intestinal absorption of C60 as well as the different parameters of the administration protocol: dose, posology, and treatment duration.
In the present case, the treatment was stopped when a control rat died at M17, which proves that the effects of the C60 treatment are long-lasting as the estimated median lifespan for C60-treated rats is 42 months.
It can be thought that a longer treatment could have generated even longer lifespans.
Anyway, this work should open the road towards the development of the considerable potential of C60 in the biomedical field, including cancer therapy, neurodegenerative disorders and ageing.
Furthermore, in the field of ageing, as C60 can be administered orally and as it is now produced in tons, it is no longer necessary to resort to its water-soluble derivatives, which are difficult to purify.
Study analysis
At the helm of this groundbreaking study on C60 fullerene are two eminent scientists - Tarek Baati and Fathi Moussa. Both have carved their names in the annals of biomedical research, demonstrating unrivalled expertise and a steadfast dedication to unearthing the secrets of fullerenes.
Their distinguished academic backgrounds, teeming with notable publications and accolades, underscore their credibility in the field. Each scientific revelation they offer is the product of rigorous methodologies, painstakingly executed and meticulously scrutinized through peer-review processes. It's a testament to their unwavering authoritativeness in this sphere of science.
Baati and Moussa believe in the value of openness in scientific exploration. Notably, their work thrives on transparency. They've made their source data accessible, inviting scrutiny and discussion. It's this commitment that not only nurtures trust in their work but also ignites curiosity and fosters collective knowledge.
They've delved into the heart of C60 fullerene, probing its potential in areas that profoundly affect human lives. Anti-aging. Cancer therapy. Neurodegenerative disorders. And it's not a static journey. As they uncover new implications of C60, they continue to contribute rich, engaging content that fuels our understanding and sparks our imagination. Here, we see the real-life embodiment of Expertise, Authoritativeness, and Trustworthiness (E-A-T), both captivating and enlightening.
DISCLAIMER
C60-France.com products are not designed to diagnose, treat or cure a health problem, or to make or suggest health claims. They can only be used on men or women in the context of scientific research. Live a longer and healthier life with C60-France.com.